Endocrine Abstracts

The question why thyroid carcinoma metastasises to the skeleton can be reformulated into the more general question why bone metastases occur in cancer.In the development of bone metastases, three phases can be distinguished.First, tumors cells have to be released into the vascular system. The process of vascular invasion and haematogenous spread involves a cascade of events that will not be summarized here, but apparent differences...

Growth hormone deficiency frequently occurs as consequence of radiation therapy in pituitary disorders. However, it not known whether radiation therapy in acromegaly results in comparable diminution of GH secretion. We therefore hypothesized that stimulated and spontaneous GH release is ultimately indistinguishable in irradiated acromegalic patients and irradiated patients with other pituitary disorders. For this study 10 acromegalic patients and 10 patients with other pituita...